Coronamonomania Lives Forever, Part 226

How much research do we need to see before everyone just acknowledges that closing schools and limiting children’s social contacts was not good for their mental health and they are having a hard time recovering.  Here is one more paper to that effect.  (Medrxiv Paper)

And the terror campaign that discouraged people from getting health care affected many disease categories, including HIV diagnoses, according to this paper.  Although missed diagnosis rates improved by 2021, there was still a gap suggesting untreated early cases, which will cause more serious disease and worse outcomes for this still major problem.  (Medrxiv Paper)

And how much research do we need showing that continuing new boosters of the vax have extremely low effectiveness against infection, while prior infection provides much better protection, particularly against a symptomatic infection.  This study from England, very well designed, again finds this to be the case.  (Medrxiv Paper)

The authors try to put a weird spin on this study, but it pretty clear suggests that the use of vaccines and other interventions to reduce spread had almost no impact on the ultimate number of infections, and that despite widespread use of those in the mid-stage of the epidemic, rates of infection were far higher than those found in the initial phase, when vaccines were not available.  (Medrxiv Paper)

Nothing surprising in this, viruses and other pathogens go through multiple rounds of replication very quickly and are designed to have high mutation rates to deal with threats to survival.  Antibiotic resistance is common.  So CV-19 should be expected to be able to mutate around potential drug treatments and according to this study, it does.  Antiviral medications like the one involved in this research, are even more likely to be linked to viral mutations, because they often work by attempting to interfere with replication genes or sequences.  (JAMA Article)

This would be hilarious if it weren’t the case that most people should avoid further CV-19 vax.  This study is largely from Moderna and uses a model (where have we seen that before) to predict that if people just get yet another updated booster this fall, millions of infections, etc. will be avoided.  In real life, every booster has shown extremely limited effectiveness, especially when the role of prior infections is taken into account.  (Medrxiv Paper)

This is a somewhat technical study relating to the use of health care codes for long-CV-19.  As you might expect with such a nebulous concept, there is wide variation in consistency of application of the code to various supposed symptoms of long-CV-19.  (Medrxiv Paper)