The federal government and the state of Minnesota continue to push for people to get multiple boosters. I have lost track of how many are recommended, and now we have the supposed Omicron booster, which I think will be equally worthless against infection. Both the regular doses and the original booster have marginal effectiveness against infection in a pretty short time. All the research indicates the same trend. From the Minnesota data, there appears to be a higher level of effectiveness for a longer time against hospitalization and death, although that needs to be assessed by age group and at least the state has failed to account for the effect of a prior infection. Other research does take that into account. It isn’t clear that a booster does anything more for you than a prior infection and a couple of doses of vaccine.
I am extremely dubious about the value of a second booster or an Omicron booster. I believe, based on my reading of the immune system research, that too much poking at the immune system with the same or similar antigens may actually have a paradoxical effect, whereby it dampens the immune response to a new attempted infection. It also is apparent that the current versions of CV-19 are very mild and the combination of some immunity from the original vax or prior infection should be adequate to protect almost everyone against serious disease. Those who are very frail and still susceptible to even a mild infection are not going to be helped by another booster. So people should make their own decisions, but I don’t see a lot of evidence that suggests continuing to take booster after booster, Omicron-specific or not, is going to make any substantial difference.
This small study from an Ohio health system looked at booster effectiveness. It found that booster effectiveness diminished quickly. Somewhat humorously, if the booster failed to protect you from getting infected, that breakthrough infection led a person to have a stronger antibody response. The authors, on anecdotal evidence, suggest a fourth shot or second booster might raise antibody response again. Why bother is again my question, when Omicron is a cold. (NEJM Study)
Do what you and your doctors think is best for you as an individual, but I am extremely doubtful that there is any lasting or significant value to most people getting additional vaccine doses.