Anthony Fauci is gone, but he is not forgotten, this is the story of Tony Rotten. Someone pointed out that Fauci’s lasting legacy will be the mistrust of science and public health he has engendered. That is not good. It is hilarious to see his constant attempts to rewrite history when everything he said lives on YouTube. The best one is he recently said on a news program that he never pushed lockdowns and someone immediately pulled up a clip of crazy Tony saying that if he could, he would have mandated a massive national lockdown. Good riddance. Unfortunately next time it will just be some other lifelong bureaucratic hack making up policy.
You may recall that I have mentioned that CV-19 will now be the 5th common seasonal coronavirus and will be with us indefinitely. And that it is likely that around the turn of the century, the 4th seasonal coronavirus, OC43, likely came into being a caused a substantial epidemic before becoming endemic. Here is an article that explores that epidemic and it’s likely association with coronavirus. (PubMed Article)
Another study from Qatar looking a Omicron variants, serious disease and the role of vaccination. The most interesting finding is that 99.8% to 99.9% of patients experienced no symptoms or mild ones. It isn’t even a cold. Despite the extremely small number of serious cases, the authors claim that vaccination was more protective than prior infection. The confidence intervals are large and I don’t believe it based on other research. (JAMA Article)
This study in adolescents is more consistent with the prior research. A prior infection provides better protection than does vaccination alone, and the protection from vax lessens more quickly. The combination of vax and prior infection provides the best protection. (Medrxiv Paper)
There have been a number of studies trying to ascertain whether taking any particular medications raises or lowers risk of contracting CV-19 or having serious disease. This study looked at proton pump inhibitors–used to stop serious indigestion and prevent ulcers, which had been implicated as a potential risk factor for respiratory infections. While there was some association with influenza or pnemonia, there did not appear to be a meaningful connection with CV-19 risk. All of these studies are fraught with confounders–unidentifed correlated factors. (Medrxiv Paper)
Here is a somewhat hilarious, although very long and very technical, review of modeling during the epidemic which ignores the obvious question–why was every model so worthless. If we don’t learn something from this pathetic episode, the next one won’t be any better. (Medrxiv Paper)
This study identified a likely shift in symptoms from earlier variants to Omicron ones. There was less loss of smell or taste during Omicron, but more sore throats, coughing and fatigue. Vaccinated and unvaxed adults showed no difference in seriousness of symptoms. (Medrxiv Paper)
The dose interval for the vaccine has been examined in several studies and a longer interval has generally been shown to afford greater protection. This study similarly found that extending the interval to 12 weeks appeared to create significantly more durable effectiveness. (Medrxiv Paper)