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Coronamonomania Lives Forever, Part 118

By March 21, 2022Commentary

On we go with the CV-19 research, even though people generally consider the epidemic to be over.

This large study from Qatar compared protection from prior infection to that from vax.  Adaptive immunity from infection was more durable and stronger than that from vax in regard to protection against a subsequent infection, but vax had an ongoing effectiveness against hospitalization and serious disease.   (Medrxiv Study)

A third dose of mRNA vaccine restored neutralizing antibodies to post-early dose levels in people with no prior CV-19 infection, but not in those with a prior infection, suggesting a limit to how many doses will be helpful, particularly given the lessening effectiveness of earlier doses.  The prior-infection group had a higher response to earlier doses than did the naive group.   (Medrxiv Study)

According to this study, there was no difference in viral load in vaxed and unvaxed persons, including when accounting for symptom level.  (JID Article)

The use of rapid antigen tests is widespread, but there has been some criticism of their potential for false negatives.  This study looked at whether RAT negatives were associated with infectious persons.  They almost never were, indicating that these tests are actually superior to PCR ones for purposes of managing the epidemic.  They are far less likely to lead to unnecessary isolation.  (Medrxiv Study)

For people who were infected early in the epidemic, antibodies were detected for up to 18 months post-infection, but the antibodies were less effective against recent variants.  (JID Article)

Omicron cases appeared to have significantly shorter hospital lengths of stay across all age groups, according to this study from Australia.  For some bizarre reason, however, the potential effect of vaccination was not included in the analysis.  (Medrxiv Study)

This article claims that mobility rates were a significant factor in case spread during the Omicron wave, but shows really pretty minor impacts and the analysis fails to account for multiple substantial confounding factors.  While it is probably true that less mobility means fewer contacts and that in turn could lead to less transmission, household transmission continues to be the single largest source of cases, so mobility likely has mixed effects.  (Medrxiv Study)

 

Join the discussion 6 Comments

  • Colonel Travis says:

    Why has Qatar been so good with research?

  • Kevin Roche says:

    single payer system in a rich country so lots of data and research resources

  • rob says:

    So is it reasonable to assume that after about 18 months there is probably zero remaining protection from either the vax or a prior infection?

  • JT says:

    I think the research needs to shift to second and third reinfections and how they compared to the original regarding symptoms and critical outcomes. I had a tough go of it, hospital stay, severe pneumonia and 2 months of oxygen support, but doing fine now. The rest of the family had head colds. Am I genetically predisposed to another bad reaction? Can the rest of the family trust that they will not have a severe reaction the second or third time? 2 of the family members were vaxxed, one a nurse, vaxxed and boosted. 2/3 of the COVID floor at the hospital was vaxxed. It’s all a crap shoot at this point with dozens, if not hundreds, of variables made up of edited, time-shifted, and partial data. It’s all worthless when it comes to answering the only question that matters; “How will I react to this virus, it’s current and future variants?”

    Maybe we should ask Jen ‘puppet’ Psaki ?

    Since it’s NOT going away, there are lots of questions that are now much more pertinent than ‘does the mRNA product work of not’. That result is known, it was a failed experiment under the criteria of a ‘vaccine’. Maybe it was a successful experiment regarding the future use of mRNA development? Maybe we should wait 5 to 7 years to see what happens to hundreds of millions of jabbed folks?

    However, they have DNA from every ‘PCR’ test, lets find the genetic marker(s) for bad reactions and focus on a very small population of people.

  • Kevin Roche says:

    typically repeat infections, or infections after vax are much milder, but there still are some serious cases, especially in older persons with frail immune systems

  • JT says:

    Good to know ….

    From now on, anything and everything C19 must be framed in how to manage an endemic virus. ALL panic and panacea regrading stopping this respiratory virus MUST END !!

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