Why has it taken two years for most people, even supposedly smart people, even our supposed experts, to recognize what was always obvious from the start of this epidemic–this is a respiratory virus, it can’t be defeated and it will determine the timetable upon which it reaches endemicity. The bigger question is when will we accept endemicity and stop the destruction of our society. Here is an editorial in the New England Journal of Medicine, one of our most prominent (and worst due to wokeness) medical journals, calling for a universal CV vaccine but also saying the following: “These sobering facts suggest that SARS-CoV-2 is unlikely to be eliminated, let alone eradicated; it will probably continue to circulate indefinitely in periodic outbreaks and endemics.” (NEJM Editorial) Ya think? Accepting this as a condition of the epidemic from the start would have allowed us to avoid all the nonsense about “flattening the curve”, etc. It was never possible to significantly affect transmission levels and it still isn’t. After spending trillions of dollars and upending everyone’s lives we are where we were always going to be. And we still have a large segment of the population, perhaps a majority, that accept all the idiotic and futile suppression attempts.
This study, once more from Israel, tracked antibody trajectory following vax for 11 months in health care workers and looked at the role of prior infection. Younger and previously infected persons had higher initial levels. All subjects experienced a decline over a few months, including those with previous infection. Boosters restored the level of antibodies, but with unclear persistence. There is also a discussion about the optimal timing for booster receipt. (Medrxiv Paper)
For whatever reason, and it probably wasn’t because of mask wearing RSV (Respiratory Syncytial Virus) disappeared for a while during the epidemic, then re-emerged in the typical off-season and is still causing a lot of serious illness in children. This article discussed the renewed wave of RSV. According to the authors’ modeling, reduced immunity build-up could lead to double the typical number of cases and hospitalizations. (JAMA Article)
This is another followup study on vaccine effectiveness from Qatar, which has a relatively young population. It found that effectiveness against infection declined to below 50% after seven months, but that protection against hospitalization or death remained very high, with little evidence of lessening. Only 35% of breakthrough cases were identified because of symptoms, the rest were identified through required testing or contact tracing. So roughly two-thirds of cases could just have been ignored. There was little effect of age and in this study, prior infection did not appear to be a factor in effectiveness. (Medrxiv Paper)
From the what did you expect department, this study from Austria finds that stringent lockdowns and isolation among the elderly substantially increase feelings of loneliness. (Medrxiv Paper)
Another study looking at rapid antigen tests and finding that they may be better at identifying who actually is infectious. (Medrxiv Paper)
Kind of an interesting study finding that the level of fungal diversity and prevalence where you live may play a role in susceptibility to serious CV-19 disease. I am sure anything that helps challenge and prime our immune system could be a factor. (Medrxiv Paper)