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Drowning in Coronavirus Research, Part 49

By July 25, 2020Commentary

This version is largely dedicated to the ongoing research on immune response to coronavirus.

This paper is an updated version of one that appeared in May, with a larger group of patients.  (Medrxiv Paper)  It was one of the first pieces of research to identify pre-existing defenses against coronavirus.  The revised version confirms the findings that persons uninfected with the current strain of coronavirus had antibodies against portions of it.  The authors note that even people infected with the current strain may have had some level of antibodies against it that caused the infection to be asymptomatic or mild.  They cautioned that prevalence surveys needed to take the pre-existing antibodies into account.  And they also warned that the restrictive lockdowns of children in particular could be hindering development of seasonal coronavirus defenses.

Another study showing strong and sustained immune response to CV infection.  (Medrxiv Paper)   The study comes from China and the researchers looked for spike and nucleocapsid antibodies among around 350 patients.  Since China had the first epidemic outbreak, they were able to study responses over a long period of time.  Antibodies developed over the course of the disease.  Certain types, more central to fighting acute infection, waned over time, but up to six months later there were strong responses from certain antibodies.  Only two patients had anomalous antibody development, indicating that for almost everyone, there will be a strong and lasting immune response.  The authors also found that the response was similar for symptomatic and asymptomatic people.

This piece of research comes from Japan and also studies immune response to CV.  (Medrxiv Paper)   In looking at 13 patients, they identified common antibody targets, which were in the spike protein (recall that spike is where the part of the virus used to get into a cell is located) but not in the actual receptor binding region of the spike.

This paper came from New York and similarly involved identifying B cell and antibody targets.  (Medrxiv Paper)   They examined 26 infected but not hospitalized patients and 21 persons who had not been exposed.  They found broad memory B cell existence in the unexposed subjects and even if circulating antibody levels were low in infected persons, they also had applicable memory B cells, which are capable of producing antibodies quickly.  86% of the unexposed group had memory B cells against a portion of the spike protein.

So the big picture that continues to evolve is that infected patients are developing a strong immune response, that persists over time.  This response consists of antibodies, memory B cells and T cells.  In addition, many people, as a result of prior infection by other strains of coronavirus, have pre-existing and cross-reactive immune responses to the current strain, including via T cells and memory B cells.


Join the discussion 2 Comments

  • mmemhopp says:

    Hi Kevin,
    I have become so disillusioned with how the governors (ours included) around our country have been chipping away at our constitutional rights and it seems as though we are all sitting back and just “taking it”. I, along with many people, feel helpless and hopeless and I do not see an end game here. This mask dictate along with what I believe the governor is going to do to the schools (shut them down), have put me over the edge. I really have been struggling with what if anything can be done. The mandates put upon us by our governor is not based on science or constitutional governance. We need debates on masks effectiveness, duration of time in use, and some sort of tools to prove to the public their effectiveness/ineffectiveness if used. I feel as though I am living in North Korea…not the USA. I know that I do not need to tell you that there really is no proven science behind mask use by the public.
    You may have already read this article in the “Conservative Review”, , but it is excellent and really sums up my feelings.

    My question to you is, are you aware of any individual/group that is exploring a legal challenge to these violations of our right? If so, I would love to help with this effort. I also have friends that would be interested.
    If you are not aware of anything in the works, would you be interested in this effort or would you know a constitutional lawyer that might?
    I feel that the time has come to stand up and let our voices be heard.

  • Killshot says:

    Agree with mm above but would suggest that the very best antidote to this poisonous toxin eroding constitutional freedoms is in the voting booth. It will basically come down to that alone IMO. The mask thing is almost a metaphor for the muting of free speech as well as a figurative diaper over the mouths of Leftists. It needs to be dealt with scientifically, yes, but also disregarded, mocked, and fought. Rape is not about sex, but rather about power. Masks are not about a few virion particles!

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